The Pertussis Serological Potency Test Collaborative Study to Evaluate Replacement of the Mouse Protection Test
نویسندگان
چکیده
منابع مشابه
Comparative Assessment of the Whole-cell Pertussis Vaccine Potency Using Serological and Intracerebral Mouse Protection Methods
One of the most important QC tests of whole-cell pertussis vaccine (WCPV) is potency test. In this regard, mouse protection test (MPT) is the current potency method, which is associated with severe animal distress and large variability in results. The purpose of this study was to assess Pertussis Serological Potency Test (PSPT) as a serological alternative method to intracerebral challenge in M...
متن کاملPertussis Serological Potency Test as an Alternative to the Intracerebral Mouse Protection Test: Development, Evaluation and Validation.
We have developed the Pertussis Serological Potency Test (PSPT) as an alternative to potency testing of pertussis Whole Cell Vaccines (WCV) in the intracerebral Mouse Protection Test (MPT). The PSPT is based on the humoral antibody response against the whole range of B. pertussis surface-antigens per vaccine dose and correlates well with the MPT. WCV-induced-antibody responses against "protecti...
متن کاملComparative analysis of the intracerebral mouse protection test and serological method for potency assays of pertussis component in DTP vaccine
The aim of this study was to compare the PSPT standardized in-house as an alternative to MPT for potency assays of pertussis component. Statistical analyses have showed similar pertussis potency values when PSPT was compared to MPT. Significant correlation between the potency results obtained by in vivo and in vitro assays was also been observed. Results by PSPT have demonstrated reproducibilit...
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ژورنال
عنوان ژورنال: Biologicals
سال: 2000
ISSN: 1045-1056
DOI: 10.1006/biol.2000.0247